Berberine (Berberine HCl) 500 mg

Supports glucose metabolism, lipid balance, and gut microbiome health with highly concentrated berberine HCl.*

What It Does
Berberine HCl 500 mg supports healthy blood sugar levels, metabolic function, and digestive health by activating key cellular pathways and maintaining microbial balance.* It helps regulate glucose and lipid metabolism while promoting a favorable gut environment that benefits immune function.*

How It Works
•    Berberine HCl (97%): A concentrated, plant-derived alkaloid that supports healthy blood glucose and lipid metabolism.*
•    AMPK Activation: Berberine activates AMP-activated protein kinase (AMPK), an enzyme that regulates glucose uptake, fat metabolism, and energy balance.*[1]
•    Blood Sugar Support: A meta-analysis of 37 studies involving 3,048 participants demonstrated berberine's ability to support glucose regulation without increasing the risk of hypoglycemia.*[2]
•    Lipid Metabolism: Berberine has been shown in placebo-controlled trials to support cholesterol and triglyceride balance, promote a healthy HDL to LDL ratio, and enhance lipid oxidation through AMPK activation.*[3,4,7]
•    Healthy Weight Management: In a six-month clinical trial, 500 mg twice daily helped maintain healthy weight and cardiometabolic markers in participants with metabolic concerns.*[3]
•    Gut Microbiome Balance: Berberine supports a healthy gut microbiota, which contributes to glucose, lipid, and immune system regulation.*[5,6]
•    Dosages: In a meta-analysis examining the effects of berberine on metabolic parameters, the most common dosage used across the included studies was 500 mg taken three times daily (1.5 g daily). Other dosing approaches were also represented, including lower daily doses such as 300 mg twice or thrice daily as well as higher doses ranging from 500 mg twice daily up to 1,000 mg three times daily.*[8]

Who It’s For
Ideal for individuals seeking support for blood sugar, lipid balance, and gastrointestinal health, particularly those focused on cardiometabolic wellness and gut-immune axis health.*

Special Features
Each capsule contains 500 mg of berberine HCl (97%), derived from non-GMO sources. Highly concentrated and standardized, this formula reflects clinically relevant dosing used in peer-reviewed studies.*

Berberine HCl 500 mg offers well-documented, multi-system support for those pursuing metabolic balance and digestive health through evidence-based plant-based supplements.*

References
1.    Yin J, et al. Am J Physiol Endocrinol Metab. 2007;294(1):E148–56.
2.    Xie W, et al. Front Pharmacol. 2022;13. doi:10.3389/fphar.2022.1015045
3.    Derosa G, et al. Expert Opin Biol Ther. 2013;13(4):475–82. 
4.    Cai Y, et al. Front Pharmacol. 2021;12. doi:10.3389/fphar.2021.631100
5.    Zhang L, et al. Front Cell Infect Microbiol. 2021;10. doi:10.3389/fcimb.2020.588517
6.    Habtemariam S. Pharmacol Res. 2020;155:104722. doi:10.1016/j.phrs.2020.104722
7.    Cai Y, et al. Front Pharmacol. 2023;14. doi:10.3389/fphar.2023.1283784
8.    Guo J, et al. Oxid Med Cell Longev. 2021;2021:2074610. doi:10.1155/2021/2074610

Suggested Use: As a dietary supplement, 1 capsule one to three times daily, or as directed by a healthcare practitioner.


Serving Size: 1 capsule

Amount Per Serving
Berberine HCl 97% ... 500mg
(from Indian Barberry) (root) (Berberis aristata)

Other Ingredients: Hydroxypropyl methylcellulose, microcrystalline cellulose, rice hull concentrate, gum arabic, sunflower oil.

Warning: Individuals with diabetes or related conditions should monitor blood glucose levels, as berberine may lower them. Not recommended during pregnancy. Breastfeeding women and children should use only under the supervision of a healthcare professional.

Keep in a cool, dry place, tightly capped.