Homocysteine Plus

Methylation Support for Homocysteine and Cellular Health*

What It Does
Homocysteine Plus provides broad-spectrum nutritional support for methylation and detoxification pathways that help maintain healthy homocysteine levels.* By supplying bioavailable methyl donors and cofactors, this formula supports cardiovascular, neurological, and cellular antioxidant function.*

How It Works
•    L-methylfolate supplies activated folate to support the methionine cycle, bypassing MTHFR polymorphisms.*[3-4]
•    Methylcobalamin is the bioactive form of vitamin B12, directly participating in methylation reactions required for homocysteine metabolism.*
•    Trimethylglycine (betaine) supports homocysteine-to-methionine conversion via the BHMT pathway, a folate-independent route active in the liver and kidneys.*
•    Serine contributes methyl groups for folate regeneration and promotes cysteine and taurine production for downstream antioxidant support.*[6]
•    Zinc is a cofactor for both methionine synthase and BHMT enzymes that catalyze the remethylation of homocysteine.*[1]
•    Vitamin B6 supports both the folate and transsulfuration pathways, supporting cysteine and glutathione synthesis.*[5]
•    Riboflavin (vitamin B2) is a required cofactor for MTHFR and may enhance folate utilization in individuals with the 677TT genotype.*[3]
•    Glutathione helps balance oxidative stress that may deplete methylation capacity by competing with SAMe synthesis for cysteine.*[7][2]
•    The homocysteine to methionine cycle contributes to the formation of SAMe (S-adenosylmethionine) SAM-e which is central to creatine, neurotransmitter, and DNA methylation pathways.*[2]

Who It’s For
Recommended for individuals looking to support healthy methylation, cardiovascular function, or antioxidant balance.*

Special Features
Combines active methyl donors, essential enzyme cofactors, and antioxidant support into a formula designed for comprehensive homocysteine and one-carbon metabolism support.*

References
1.    Jing M et al. J Trace Elem Med Biol. 2015;30:77–82.
2.    Bottiglieri T. Am J Clin Nutr. 2002;76(5):1151S–7S.
3.    McNulty H et al. Circulation. 2006;113(1):74–80.
4.    McNulty H et al. Curr Dev Nutr. 2020;4(1):nzz102.
5.    Ubbink JB et al. J Clin Invest. 1996;98(1):177–84.
6.    Kalhan S, Hanson R. J Biol Chem. 2012;287(24):19786–91.
7.    Wang L et al. Exp Ther Med. 2020;20(2):938–44.

As a dietary supplement, 1 capsule one or two times daily with meals, or as directed by a healthcare practitioner.

Serving Size: 1 capsule

Amount Per Serving:
Vitamin B2 ... 10mg
(as Riboflavin-5-Phosphate)
Vitamin B6 ... 30mg
(50% as Pyridoxine Hydrochloride and 50% as Pyridoxal-5-Phosphate)
5-Methyltetrahydrofolate ... 400µg
(from 740 μg [6S]-5-methyltetrahydrofolic acid, glucosamine salt)
Vitamin B12 ... 400µg
(as Methylcobalamin)
Zinc Picolinate ... 5mg
Trimethylglycine ... 500mg
L-Serine ... 100mg
L-Glutathione (reduced) ... 50mg

Other Ingredients: Hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, silicon dioxide.

Warning: If you experience any fatigue or adverse reaction, reduce dose or discontinue use.

Variations in product color may occur. Keep in a cool, dry place, tightly capped.